Station 4 of 13 · Molecule · the record
Incensole acetate
Incensole acetate, C22H36O3, is the diterpene the house’s frankincense essay names as its key compound. Its identity is PubChem’s; it has been isolated from Boswellia sacra resin.
A study in mice found that it activates TRPV3 channels in the brain, with anxiolytic-like effects; its authors suggest this “may” bear on religious traditions. What it means for people burning the resin is not established.
The record
Each field carries its evidence: open a chip for the source, the quoted words and the confidence. A field with nothing behind it says so and stays empty.
- Name
- incensole acetate
documented
Incensole acetate
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
confidence A
- CAS
- 34701-53-6
documented
34701-53-6
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
among the CID’s PubChem synonyms, and PubChem resolves it back to this CID
confidence A
- PubChem CID
- 53386731
documented
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
confidence A
- Formula
- C22H36O3
documented
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
confidence A
- Molecular weight
- 348.5
documented
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
g/mol, as PubChem states it
confidence A
- IUPAC name
- [(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] acetate
documented
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
confidence A
- SMILES
- C/C/1=C\CC/C(=C/C[C@@]2(CC[C@@](O2)([C@H](CC1)OC(=O)C)C)C(C)C)/C
documented
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
confidence A
- InChIKey
- HVBACKJYWZTKCA-XSLBTUIJSA-N
documented
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
confidence A
- Odour threshold
- withheld: not on record
withheld
no odour-threshold measurement is filed: OT-1 has no entry and the study on file (GC-17) measures pharmacology, not odour (the house’s review, 2026-09-30)
- Descriptors
- not on record
not on record
no descriptor on record: no house wording on a data file, no descriptor source filed
- Volatility class
- not on record
not on record
the simulator’s data (modeled) has no entry for incensole acetate
- Regulation
- not on record
not on record
no Regulation record yet
- 3D structure
- PubChem computed 3D conformer · 61 atoms, 62 bonds
modeled
PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-tri · read 2026-09-30
PubChem’s computed 3D conformer (the 3D SDF record): a model, drawn schematically, not an experimental structure
confidence A
- Occurs in
- frankincense (the oleo-gum resin of Boswellia; olibanum)
documented · no share
isolated from B. sacra gum resin (cited by GC-16)
confidence B
- frankincense (the oleo-gum resin of Boswellia; olibanum)
Claims register
Every sentence and number the site states about this record, with its status after the 2026-09-27 review.
- softened · Laboratory studies in animals have reported effects of incensole acetate, a compound in the resin; what that means for people burning it is not established. (was: Recent neuroscience research suggests incensole acetate (a compound in frankincense) has psychoactive properties, activating TRPV3 receptors and potentially explaining the contemplative states reported during religious burning.)
documented · register row 2283
GC-17 · Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM · read 2026-09-30
GC-17 (abstract): incensole acetate, “a Boswellia resin constituent”, is a TRPV3 agonist with anxiolytic-like and antidepressive-like effects in mice (GC-17); the authors’ own hedge is “may provide a biological basis” (GC-17). The softened sentence is supported as it stands
where the site says it: /materials, “Omani Frankincense”
confidence A
Sources
- PUBCHEM-53386731 · PubChem Compound Summary for CID 53386731, Incensole acetate ([(1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-propan-2-yl-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl] acetate). National Center for Biotechnology Information (NCBI), U.S. National Library of Medicine; live database, read 2026-09-30 through the PUG REST endpoints (no account): https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/incensole%20acetate/cids/JSON · https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/53386731/property/MolecularFormula,MolecularWeight,IUPACName,Title,SMILES,InChIKey/JSON · https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/53386731/synonyms/JSON · https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/cid/53386731/SDF?record_type=3d · https://pubchem.ncbi.nlm.nih.gov/rest/pug/compound/name/34701-53-6/cids/JSON. pubchem.ncbi.nlm.nih.gov/compound/53386731 · read 2026-09-30 · PubChem data are provided by NCBI (public-domain data; cite PubChem, the asset register molecules row); the computed conformer is PubChem-generated. The raw responses are filed as fetched (the house’s records).
- GC-16 · Miran M, Amirshahrokhi K, Ajanii Y, Zadali R, Rutter MW, Enayati A, Movahedzadeh F. Taxonomical Investigation, Chemical Composition, Traditional Use in Medicine, and Pharmacological Activities of Boswellia sacra Flueck. Evidence-Based Complementary and Alternative Medicine 2022;2022:8779676. DOI 10.1155/2022/8779676. PMID 35222678. PMCID PMC8881160. doi.org/10.1155/2022/8779676 · read 2026-09-30 · Creative Commons Attribution License (open access, as the article states); short quotes only, the text is not filed
- GC-17 · Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E, Mechoulam R. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. The FASEB Journal 2008;22(8):3024–3034. DOI 10.1096/fj.07-101865. PMID 18492727. PMCID PMC2493463. doi.org/10.1096/fj.07-101865 · read 2026-09-30
These records are published under CC BY 4.0.
this record as data: /data/molecule/incensole-acetate.json · version 2 · updated 2026-09-30 · confidence A